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Insights into the role of the von Hippel-Lindau gene product. A key player in hypoxic regulation.

Abstract:

Many adaptive responses to hypoxia involve changes in gene transcription mediated by the hypoxia-inducible factor 1 complex. Central to this is oxygen-dependent proteolysis of the alpha subunit, which has recently been shown to require the von Hippel-Lindau tumour-suppressor protein. This observation provides one mechanism by which inherited defects in the von Hippel-Lindau gene could cause features of the clinical syndrome, and offers insight into the events leading to sporadic clear cell re...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, BHF Centre of Research Excellence
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, Biomedical Research Centre
Role:
Author
Journal:
Experimental nephrology
Volume:
9
Issue:
4
Pages:
235-240
Publication date:
2001-01-01
ISSN:
1018-7782
URN:
uuid:09886fcd-3671-4bf7-ad76-08f785e7cf69
Source identifiers:
8236
Local pid:
pubs:8236

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