Journal article
Neuroprotection achieved with a novel proteasome inhibitor which blocks NF-kappaB activation.
- Abstract:
-
Activated NF-kappaB contributes to cerebral infarction by triggering a neuro-inflammatory response. Rats subjected to 90min middle cerebral artery occlusion developed a cortical infarct of 20+/-4% of hemispheric volume (n = 8). Treatment with the proteasome inhibitor CVT-634 resulted in a significantly smaller infarct of 13+/-2% (n = 7, p<0.01) and 12+/-2% (n = 8, p<0.001) of hemispheric volume at 1 day and 7 days, respectively. Since regional cerebral blood flows for the core and penum...
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- Publication status:
- Published
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- Publisher copy:
- 10.1097/00001756-200002070-00041
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Bibliographic Details
- Journal:
- Neuroreport
- Volume:
- 11
- Issue:
- 2
- Pages:
- 427-430
- Publication date:
- 2000-02-01
- DOI:
- EISSN:
-
1473-558X
- ISSN:
-
0959-4965
- Source identifiers:
-
79156
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:79156
- UUID:
-
uuid:09854499-62c8-496a-8fe9-0be97c24ca80
- Local pid:
- pubs:79156
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2000
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