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Neuroprotection achieved with a novel proteasome inhibitor which blocks NF-kappaB activation.

Abstract:

Activated NF-kappaB contributes to cerebral infarction by triggering a neuro-inflammatory response. Rats subjected to 90min middle cerebral artery occlusion developed a cortical infarct of 20+/-4% of hemispheric volume (n = 8). Treatment with the proteasome inhibitor CVT-634 resulted in a significantly smaller infarct of 13+/-2% (n = 7, p<0.01) and 12+/-2% (n = 8, p<0.001) of hemispheric volume at 1 day and 7 days, respectively. Since regional cerebral blood flows for the core and penum...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Stroke and Geratology
Role:
Author
Journal:
Neuroreport
Volume:
11
Issue:
2
Pages:
427-430
Publication date:
2000-02-01
DOI:
EISSN:
1473-558X
ISSN:
0959-4965
Source identifiers:
79156

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