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Mucosal-associated invariant T-cells: new players in anti-bacterial immunity.

Abstract:

Mucosal-associated invariant T (MAIT) cells are an innate-like T-cell population involved in anti-bacterial immunity. In human beings, MAIT cells are abundant, comprising ~10% of the CD8(+) T-cell compartment in blood. They are enriched at mucosal sites and are particularly prevalent within the liver. MAIT cells are defined by the expression of a semi-invariant T-cell receptor (Vα7.2-Jα33/12/20) and are restricted by the non-polymorphic, highly evolutionarily conserved MHC class Ib molecule, ...

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Publisher copy:
10.3389/fimmu.2014.00450

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Publisher:
Frontiers Research Foundation
Journal:
Frontiers in immunology
Volume:
5
Issue:
OCT
Pages:
450
Publication date:
2014-01-01
DOI:
EISSN:
1664-3224
Source identifiers:
488368
Language:
English
Keywords:
Pubs id:
pubs:488368
UUID:
uuid:097fecab-7f81-4bbf-8ced-d31062bc22b0
Local pid:
pubs:488368
Deposit date:
2014-11-04

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