Journal article
Modulation of THP-1 macrophage and cholesterol-loaded foam cell apolipoprotein E levels by glycosphingolipids.
- Abstract:
-
Macrophages synthesize and secrete apolipoprotein E (apoE) constitutively. This process is upregulated under conditions of cholesterol loading. The response to cholesterol is antiatherogenic as it is believed to promote cholesterol efflux from the artery wall. The concentration of lactosyl ceramide (LacCer), a glycosphingolipid recently discovered to regulate cellular signaling, proliferation, and expression of adhesion molecules, is also increased in atherosclerotic tissues. Here we have inv...
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- Publication status:
- Published
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- Publisher copy:
- 10.1006/bbrc.2002.6356
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Authors
Bibliographic Details
- Journal:
- Biochemical and biophysical research communications
- Volume:
- 290
- Issue:
- 5
- Pages:
- 1361-1367
- Publication date:
- 2002-02-01
- DOI:
- EISSN:
-
1090-2104
- ISSN:
-
0006-291X
- Source identifiers:
-
100959
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:100959
- UUID:
-
uuid:097dfc65-7dfa-4caf-9869-dd21c97f268f
- Local pid:
- pubs:100959
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2002
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