- Abstract:
-
Macrophages synthesize and secrete apolipoprotein E (apoE) constitutively. This process is upregulated under conditions of cholesterol loading. The response to cholesterol is antiatherogenic as it is believed to promote cholesterol efflux from the artery wall. The concentration of lactosyl ceramide (LacCer), a glycosphingolipid recently discovered to regulate cellular signaling, proliferation, and expression of adhesion molecules, is also increased in atherosclerotic tissues. Here we have inv...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1006/bbrc.2002.6356
-
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- Journal:
- Biochemical and biophysical research communications
- Volume:
- 290
- Issue:
- 5
- Pages:
- 1361-1367
- Publication date:
- 2002-02-05
- DOI:
- EISSN:
-
1090-2104
- ISSN:
-
0006-291X
- URN:
-
uuid:097dfc65-7dfa-4caf-9869-dd21c97f268f
- Source identifiers:
-
100959
- Local pid:
- pubs:100959
- Copyright date:
- 2002
Journal article
Modulation of THP-1 macrophage and cholesterol-loaded foam cell apolipoprotein E levels by glycosphingolipids.
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