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Journal article

Novel small-molecule inhibitors of arylamine N-acetyltransferases: drug discovery by high-throughput screening.

Abstract:

Arylamine N-acetyltransferases (NATs) are a family of enzymes found in eukaryotes and prokaryotes. While the precise endogenous function of NAT remains unknown for most organisms, recent evidence has shown that the expression of human NAT1 is up-regulated in estrogen receptor positive breast cancer. Additionally, NAT in mycobacteria is required for mycobacterial cell wall biosynthesis and survival of the organisms within macrophage. It is therefore important to develop small molecule inhibito...

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Publication status:
Published

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Publisher copy:
10.2174/138620711794474051

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Combinatorial chemistry and high throughput screening More from this journal
Volume:
14
Issue:
2
Pages:
117-124
Publication date:
2011-02-01
DOI:
EISSN:
1875-5402
ISSN:
1386-2073
Language:
English
Keywords:
Pubs id:
pubs:103614
UUID:
uuid:097bfd2c-a6d3-4af7-8aa9-d60a1a3cbcbe
Local pid:
pubs:103614
Source identifiers:
103614
Deposit date:
2012-12-19

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