Randomized clinical trial of the effects of preoperative and postoperative oral nutritional supplements on clinical course and cost of care.

Smedley, F; Bowling, T; James, M; Stokes, E; Goodger, C; O'Connor, O; Oldale, C; Jones, P; Silk, D

Journal article

Randomized clinical trial of the effects of preoperative and postoperative oral nutritional supplements on clinical course and cost of care.

Abstract:: BACKGROUND: Postoperative oral nutritional supplementation has been shown to be of clinical benefit. This study examined the clinical effects and cost of administration of oral supplements both before and after surgery. METHODS: This was a randomized clinical trial conducted in three centres. Patients undergoing lower gastrointestinal tract surgery were randomized to one of four groups: group CC received no nutritional supplements, group SS took supplements both before and after surgery, group CS received postoperative supplements only, and group SC were given supplements only before surgery. Preoperative supplements were given from the time it was decided to operate to 1 day before surgery. Postoperative supplements were started when the patient was able to take free fluids and continued for 4 weeks after discharge from hospital. Data collected included weight change, complications, length of stay, nutritional intake, anthropometrics, quality of life and detailed costings covering all aspects of care. RESULTS: Some 179 patients were randomized, of whom 27 were withdrawn and 152 analysed (CC 44, SS 32, CS 35, SC 41). Dietary intake was similar in all four groups throughout the study. Mean energy intake from preoperative supplements was 536 and 542 kcal/day in the SS and SC groups respectively; that 2 weeks after discharge from hospital was 274 and 361 kcal/day in the SS and CS groups respectively. There was significantly less postoperative weight loss in the SS group than in the CC and CS groups (P < 0.050), and significantly fewer minor complications in the SS and CS groups than the CC group (P < 0.050). There were no differences in the rate of major complications, anthropometrics and quality of life. Mean overall costs were greatest in the CC group, although differences between groups were not significant. CONCLUSION: Perioperative oral nutritional supplementation started before hospital admission for lower gastrointestinal tract surgery significantly diminished the degree of weight loss and incidence of minor complications, and was cost-effective.

Actions

Email

Email this record

Send the bibliographic details of this record to your email address.

Your Email
Please enter the email address that the record information will be sent to.

-
Your message (optional)
Please add any additional information to be included within the email.
Share
Cite

Cite this record

APA Style

Smedley, F., Bowling, T., James, M., Stokes, E., Goodger, C., O'Connor, O., Oldale, C., Jones, P., & Silk, D. (2004). Randomized clinical trial of the effects of preoperative and postoperative oral nutritional supplements on clinical course and cost of care. British Journal of Surgery, 91(8), 983–990.

MLA Style

Smedley, F, et al. “Randomized Clinical Trial of the Effects of Preoperative and Postoperative Oral Nutritional Supplements on Clinical Course and Cost of Care.” British Journal of Surgery, vol. 91, no. 8, 2004, pp. 983–90.

Chicago Style

Smedley, F, T Bowling, M James, et al. 2004. “Randomized Clinical Trial of the Effects of Preoperative and Postoperative Oral Nutritional Supplements on Clinical Course and Cost of Care.” British Journal of Surgery 91 (8): 983–90.
Print