Spontaneous and drug-induced rotation following localized 6-hydroxydopamine and kainic acid-induced lesions of the neostriatum.

Journal article

Twelve groups of rats received small localized lesions produced by either 6-hydroxydopamine (6-OHDA) or kainic acid (KA) in one of six placements in the right neostriatum. All groups lesioned with 6-OHDA showed ipsilateral spontaneous and amphetamine-induced rotation and contralateral apomorphine-induced rotation. All groups lesioned with kainic acid showed ipsilateral spontaneous rotation on day 1 following the lesion but contralateral rotation by day 8, and no significant rotation to inject...

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Authors: Dunnett, S; Iversen, S

• Publication status: Published
• Journal: Neuropharmacology
• Volume: 21
• Issue: 9
• Pages: 899-908
• Publication date: 1982-09-01
• DOI: 10.1016/0028-3908(82)90082-x
• EISSN: 1873-7064
• ISSN: 0028-3908
• Language: English
• Keywords: Kainic Acid; Rotation; Hydroxydopamines; Corpus Striatum; Animals; Putamen; Male; Functional Laterality; Caudate Nucleus; Oxidopamine; Rats; Rats, Inbred Strains; Pyrrolidines; Motor Activity