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Spontaneous and drug-induced rotation following localized 6-hydroxydopamine and kainic acid-induced lesions of the neostriatum.

Abstract:

Twelve groups of rats received small localized lesions produced by either 6-hydroxydopamine (6-OHDA) or kainic acid (KA) in one of six placements in the right neostriatum. All groups lesioned with 6-OHDA showed ipsilateral spontaneous and amphetamine-induced rotation and contralateral apomorphine-induced rotation. All groups lesioned with kainic acid showed ipsilateral spontaneous rotation on day 1 following the lesion but contralateral rotation by day 8, and no significant rotation to inject...

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Publication status:
Published

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Authors


Dunnett, SB More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Journal:
Neuropharmacology
Volume:
21
Issue:
9
Pages:
899-908
Publication date:
1982-09-05
DOI:
EISSN:
1873-7064
ISSN:
0028-3908
URN:
uuid:09779791-a160-4e3f-8053-b3fa0e906696
Source identifiers:
26790
Local pid:
pubs:26790

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