Twelve groups of rats received small localized lesions produced by either 6-hydroxydopamine (6-OHDA) or kainic acid (KA) in one of six placements in the right neostriatum. All groups lesioned with 6-OHDA showed ipsilateral spontaneous and amphetamine-induced rotation and contralateral apomorphine-induced rotation. All groups lesioned with kainic acid showed ipsilateral spontaneous rotation on day 1 following the lesion but contralateral rotation by day 8, and no significant rotation to inject...Expand abstract
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Spontaneous and drug-induced rotation following localized 6-hydroxydopamine and kainic acid-induced lesions of the neostriatum.
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