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Crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1.8 A resolution.

Abstract:

The cell-surface glycoprotein vascular cell adhesion molecule-1 (VCAM-1; ref. 1) mediates intercellular adhesion by specific binding to the integrin very-late antigen-4 (VLA-4, alpha 4 beta 1; ref. 3). VCAM-1, with the intercellular adhesion molecules ICAM-1, ICAM-2, ICAM-3 and the mucosal vascular addressin MAd-CAM-1, forms an integrin-binding subgroup of the immunoglobulin superfamily. In addition to their clinical relevance in inflammation, these molecules act as cellular receptors for vir...

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Publication status:
Published

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Publisher copy:
10.1038/373539a0

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Role:
Author
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Journal:
Nature
Volume:
373
Issue:
6514
Pages:
539-544
Publication date:
1995-02-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:09765b28-d64d-4481-b329-d20ab84123df
Source identifiers:
25603
Local pid:
pubs:25603

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