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Reversal of the effects of a low extracellular potassium concentration on the number and activity of Na+/K+ pumps in an Epstein-Barr virus-transformed human lymphocyte cell line.

Abstract:

A reduction in the extracellular concentration of potassium to 0.5 mM (low K) in Epstein-Barr (EB) virus-transformed lymphocytes caused changes in the number and activity of Na+/K+ pumps in the cell membrane, with increases in the Bmax and apparent Kd of ouabain binding, and concomitant increases in the Vmax and apparent Km of potassium (rubidium) influx. However, recovery from the effects of low K occurred more quickly than the original up-regulation. Furthermore, there were differences in t...

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Publication status:
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Institution:
University of Oxford
Division:
MSD
Department:
Primary Care Health Sciences
Role:
Author
Journal:
Biochemical pharmacology More from this journal
Volume:
43
Issue:
3
Pages:
489-496
Publication date:
1992-02-01
DOI:
EISSN:
1873-2968
ISSN:
0006-2952
Language:
English
Keywords:
Pubs id:
pubs:322034
UUID:
uuid:096feb59-f808-4ec2-b60a-2523c2c4a578
Local pid:
pubs:322034
Source identifiers:
322034
Deposit date:
2012-12-19

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