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Distinct patterns of HIV-1 evolution within metastatic tissues in patients with non-Hodgkins lymphoma.

Abstract:

Despite highly active antiretroviral therapy (HAART), AIDS related lymphoma (ARL) occurs at a significantly higher rate in patients infected with the Human Immunodeficiency Virus (HIV) than in the general population. HIV-infected macrophages are a known viral reservoir and have been shown to have lymphomagenic potential in SCID mice; therefore, there is an interest in determining if a viral component to lymphomagenesis also exists. We sequenced HIV-1 envelope gp120 clones obtained post mortem...

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Journal:
PloS one
Volume:
4
Issue:
12
Pages:
e8153
Publication date:
2009-01-01
DOI:
EISSN:
1932-6203
URN:
uuid:096bef77-07d3-4d97-9c77-c8e5459e5805
Source identifiers:
315463
Local pid:
pubs:315463

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