Structures of the TMC-1 complex illuminate mechanosensory transduction

Journal article

Hearing and touch are two of our senses that rely on mechanotransduction to convert mechanical stimulus into electrochemical activity. Several studies have demonstrated that touch and hearing share common genetic determinants; mutations in genes causing deafness are also associated with reduced tactile sensitivity. Furthermore, transcriptome analysis from several studies has revealed that the same genes are expressed in both systems. However, the role of these genes has yet to be determined. ...

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Authors: Jeong, H; Clark, S; Goehring, A; Dehghani-Ghahnaviyeh, S; Rasouli, A

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Nature Research
• Journal: Nature
• Volume: 610
• Issue: 7933
• Pages: 796-803
• Publication date: 2022-10-12
• DOI: 10.1038/s41586-022-05314-8
• EISSN: 1476-4687
• ISSN: 0028-0836
• Language: English
• Keywords: Biochemistry; Biophysics; Transmembrane protein; Membrane; Chemistry; Protein subunit; Cell biology; Biology; Gating; Transduction (biophysics); Signal transduction; Protein structure; Receptor; Mechanotransduction; Transmembrane domain