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The ability of Fos family members to produce phenotypic changes in epithelioid cells is not directly linked to their transactivation potentials.

Abstract:

Numerous studies have revealed distinct functions of Fos proteins in different mouse tissues and cell lines. Here, we perform a direct comparison of the features of exogenous c-Fos, Fra-1 and Fra-2 proteins expressed in murine tumor cells of epithelial origin, CSML0. Although transactivation potential of c-Fos is much stronger than that of Fra-1 and Fra-2, all three proteins are capable of modulating transcription of target genes. Moreover, there is a certain degree of specificity in the indu...

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Publisher copy:
10.1038/sj.onc.1205590

Authors


Journal:
Oncogene More from this journal
Volume:
21
Issue:
31
Pages:
4843-4848
Publication date:
2002-07-01
DOI:
EISSN:
1476-5594
ISSN:
0950-9232
Language:
English
Keywords:
Pubs id:
pubs:374992
UUID:
uuid:096bc3d1-d65b-4e22-8533-46b42645eeb6
Local pid:
pubs:374992
Source identifiers:
374992
Deposit date:
2013-11-17

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