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The isolation and characterisation of the genes coding for the calcium channel affected by Lambert-Eaton myasthenic syndrome antibodies in NG108-15 cells

Abstract:

Lambert-Eaton myasthenic syndrome is a rare paraneoplastic and autoimmune disorder affecting the presynaptic voltage gated calcium channels at the neuromuscular junction. The aim of this project was to isolate the genes coding for the α1 and α2 subunits of the voltage-gated calcium channel from hybrid neuronal cell lines including NG108-15 whose potassium stimulated 45Ca2+ flux is reduced by IgG from patients with Lambert-Eaton myasthenic syndrome.

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Peer review status:
Peer reviewed

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Department:
University of Oxford
Role:
Author
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Source identifiers:
603840901
UUID:
uuid:096b02c9-8c80-4f82-8d4c-8ed2ca59aa2e
Local pid:
polonsky:2:53
Deposit date:
2017-10-04

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