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Haplotype construction of the FRDA gene and evaluation of its role in type II diabetes.

Abstract:

A GAA-repeat in the X25 gene is causing Friedreich's ataxia (FRDA), a common neurodegenerative disease and >20% of FRDA patients develop type II diabetes (T2D). Linkage has previously been detected between T2D and chromosome 9p13-q21, the region that harbours the X25 gene, but association studies of this gene in T2D have been contradicting. Here, we examined whether genetic variation in the X25 gene is associated with risk for T2D. The GAA-repeat and 18 single nucleotide polymorphisms (SNP...

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Publication status:
Published

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Publisher copy:
10.1038/sj.ejhg.5201413

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Journal:
European journal of human genetics : EJHG
Volume:
13
Issue:
7
Pages:
849-855
Publication date:
2005-07-05
DOI:
EISSN:
1476-5438
ISSN:
1018-4813
URN:
uuid:0969a84d-6d7a-457a-9f04-5099f786e159
Source identifiers:
10972
Local pid:
pubs:10972

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