Somatostatin analogs modulate AIP in somatotroph adenomas: the role of the ZAC1 pathway.

Journal article

CONTEXT: Somatotroph adenomas harboring aryl hydrocarbon receptor interacting protein (AIP) mutations respond less well to somatostatin analogs, suggesting that the effects of somatostatin analogs may be mediated by AIP. OBJECTIVE: The objective of the investigation was to study the involvement of AIP in the mechanism of effect of somatostatin analogs. DESIGN: In the human study, a 16-wk somatostatin analog pretreatment compared with no pretreatment. In the in vitro cell line study, the effe...

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Authors: Chahal, H; Trivellin, G; Leontiou, C; Alband, N; Fowkes, R

• Publication status: Published
• Journal: Journal of clinical endocrinology and metabolism
• Volume: 97
• Issue: 8
• Pages: E1411-E1420
• Publication date: 2012-08-01
• DOI: 10.1210/jc.2012-1111
• EISSN: 1945-7197
• ISSN: 0021-972X
• Language: English
• Keywords: Somatostatin; Transcription Factors; Receptors, Somatostatin; Tumor Suppressor Proteins; Animals; Signal Transduction; Rats; Cell Line, Tumor; Adenoma; Humans; Cell Cycle Proteins; Growth Hormone-Secreting Pituitary Adenoma; Intracellular Signaling Peptides and Proteins