Journal article icon

Journal article

Crystal structure and DNA repair activities of the AP endonuclease from Leishmania major.

Abstract:

Apurinic/apyrimidinic endonucleases initiate the repair of abasic sites produced either spontaneously, from attack of bases by reactive oxygen species or as intermediates during base excision repair. The catalytic properties and crystal structure of Leishmania major apurinic/apyrimidinic endonuclease are described and compared with those of human APE1 and bacterial exonuclease III. The purified enzyme is shown to possess apurinic/apyrimidinic endonuclease activity of the same order as eukaryo...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1016/j.jmb.2007.08.001

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Structural Biology
Role:
Author
Expand authors...
Journal:
Journal of molecular biology
Volume:
373
Issue:
4
Pages:
827-838
Publication date:
2007-11-05
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:09620ea0-b7ce-456f-a7bc-e68537fb8286
Source identifiers:
33973
Local pid:
pubs:33973

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP