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Plasmodium falciparum drug resistance phenotype as assessed by patient antimalarial drug levels and its association with pfmdr1 polymorphisms.

Abstract:

BACKGROUND: Multidrug-resistant Plasmodium falciparum is a major threat to global malaria control. Parasites develop resistance by gradually acquiring genetic polymorphisms that decrease drug susceptibility. The aim of this study was to investigate the extent to which parasites with different genetic characteristics are able to withstand individual drug blood concentrations. METHODS: We analyzed 2 clinical trials that assessed the efficacy and effectiveness of artemether-lumefantrine. As a pr...

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Publication status:
Published

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Publisher copy:
10.1093/infdis/jis747

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Journal:
Journal of infectious diseases More from this journal
Volume:
207
Issue:
5
Pages:
842-847
Publication date:
2013-03-01
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
Language:
English
Keywords:
Pubs id:
pubs:389924
UUID:
uuid:095e4b81-59cd-41f2-a3b7-63d8acad2700
Local pid:
pubs:389924
Source identifiers:
389924
Deposit date:
2014-02-13

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