Plasmodium falciparum drug resistance phenotype as assessed by patient antimalarial drug levels and its association with pfmdr1 polymorphisms.

Journal article

BACKGROUND: Multidrug-resistant Plasmodium falciparum is a major threat to global malaria control. Parasites develop resistance by gradually acquiring genetic polymorphisms that decrease drug susceptibility. The aim of this study was to investigate the extent to which parasites with different genetic characteristics are able to withstand individual drug blood concentrations. METHODS: We analyzed 2 clinical trials that assessed the efficacy and effectiveness of artemether-lumefantrine. As a pr...

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Authors: Malmberg, M; Ferreira, P; Tarning, J; Ursing, J; Ngasala, B

• Publication status: Published
• Journal: Journal of infectious diseases
• Volume: 207
• Issue: 5
• Pages: 842-847
• Publication date: 2013-03-01
• DOI: 10.1093/infdis/jis747
• EISSN: 1537-6613
• ISSN: 0022-1899
• Language: English
• Keywords: Fluorenes; Recurrence; Artemisinins; Clinical Trials as Topic; Ethanolamines; Plasmodium falciparum; Child, Preschool; Humans; Female; Polymorphism, Single Nucleotide; Drug Combinations; Infant; Multidrug Resistance-Associated Proteins; Drug Resistance; Male; Antimalarials