Change in MRI-detected subchondral bone marrow lesions is associated with cartilage loss: the MOST Study. A longitudinal multicentre study of knee osteoarthritis.

Journal article

OBJECTIVES: To describe the natural history of subchondral bone marrow lesions (BMLs) in a sample of subjects with knee osteoarthritis (OA) or at risk of developing it. Additionally, to examine the association of change in BMLs from baseline to 30-month follow-up with the risk of cartilage loss in the same subregion at follow-up. METHODS: 1.0 T MRI was performed using proton density-weighted, fat-suppressed sequences. BML size and cartilage status were scored in the same subregions according ...

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Authors: Roemer, F; Guermazi, A; Javaid, M; Lynch, J; Niu, J

• Publication status: Published
• Journal: Annals of the rheumatic diseases
• Volume: 68
• Issue: 9
• Pages: 1461-1465
• Publication date: 2009-09-01
• DOI: 10.1136/ard.2008.096834
• EISSN: 1468-2060
• ISSN: 0003-4967
• Language: English
• Keywords: Humans; Follow-Up Studies; Osteoarthritis, Knee; Middle Aged; Cartilage, Articular; Female; Prospective Studies; Magnetic Resonance Imaging; Male; MOST Study investigators; Bone Marrow Diseases; Aged; Knee Joint; Image Interpretation, Computer-Assisted; Disease Progression