Journal article icon

Journal article

Cutting edge: back to "one-way" germinal centers

Abstract:

The present status of germinal center (GC) research is revisited using in silico simulations based on recent lymphocyte motility data in mice. The generally adopted view of several rounds of somatic hypermutations and positive selection is analyzed with special emphasis on the spatial organization of the GC reaction. We claim that the development of dark zones is not necessary for successful GC reactions to develop. We find that a recirculation of positively selected centrocytes to the dark z...

Expand abstract

Actions


Access Document


Files:
Publication date:
2005-01-01
UUID:
uuid:094be933-2494-43e4-b1f2-ff833128a9bd
Local pid:
oai:eprints.maths.ox.ac.uk:350
Deposit date:
2011-05-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP