Journal article
RNA therapy for polyglutamine neurodegenerative diseases.
- Abstract:
-
Polyglutamine neurodegenerative diseases result from the expansion of a trinucleotide CAG repeat, encoding a polyglutamine tract in the disease-causing protein. The process by which each polyglutamine protein exerts its toxicity is complex, involving a variety of mechanisms including transcriptional dysregulation, proteasome impairment and mitochondrial dysfunction. Thus, the most effective and widely applicable therapies are likely to be those designed to eliminate production of the mutant p...
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- Publisher copy:
- 10.1017/erm.2011.1
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Authors
Bibliographic Details
- Journal:
- Expert reviews in molecular medicine
- Volume:
- 14
- Pages:
- e3
- Publication date:
- 2012-01-01
- DOI:
- EISSN:
-
1462-3994
- ISSN:
-
1462-3994
- Source identifiers:
-
245896
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:245896
- UUID:
-
uuid:0949482a-8361-4755-8e2d-fe93d1710866
- Local pid:
- pubs:245896
- Deposit date:
- 2013-02-20
Terms of use
- Copyright date:
- 2012
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