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RNA therapy for polyglutamine neurodegenerative diseases.

Abstract:

Polyglutamine neurodegenerative diseases result from the expansion of a trinucleotide CAG repeat, encoding a polyglutamine tract in the disease-causing protein. The process by which each polyglutamine protein exerts its toxicity is complex, involving a variety of mechanisms including transcriptional dysregulation, proteasome impairment and mitochondrial dysfunction. Thus, the most effective and widely applicable therapies are likely to be those designed to eliminate production of the mutant p...

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Publisher copy:
10.1017/erm.2011.1

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Expert reviews in molecular medicine
Volume:
14
Pages:
e3
Publication date:
2012-01-01
DOI:
EISSN:
1462-3994
ISSN:
1462-3994
Source identifiers:
245896
Language:
English
Keywords:
Pubs id:
pubs:245896
UUID:
uuid:0949482a-8361-4755-8e2d-fe93d1710866
Local pid:
pubs:245896
Deposit date:
2013-02-20

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