Acid-sensing ion channel 1 is involved in both axonal injury and demyelination in multiple sclerosis and its animal model

Journal article

Although there is growing evidence for a role of excess intracellular cations, particularly calcium ions, in neuronal and glial cell injury in multiple sclerosis, as well as in non-inflammatory neurological conditions, the molecular mechanisms involved are not fully determined. We previously showed that the acid-sensing ion channel 1 which, when activated under the acidotic tissue conditions found in inflammatory lesions opens to allow influx of sodium and calcium ions, contributes to axonal ...

Expand abstract

Authors: Vergo, S; Craner, M; Etzensperger, R; Attfield, K; Friese, M

• Journal: Brain
• Volume: 134
• Issue: 2
• Pages: 571-584
• Publication date: 2011-02-01
• DOI: 10.1093/brain/awq337
• EISSN: 1460-2156
• ISSN: 0006-8950
• Language: English
• Keywords: acid-sensing ion channel; amiloride; multiple sclerosis; neuroprotection; demyelination