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Acid-sensing ion channel 1 is involved in both axonal injury and demyelination in multiple sclerosis and its animal model

Abstract:

Although there is growing evidence for a role of excess intracellular cations, particularly calcium ions, in neuronal and glial cell injury in multiple sclerosis, as well as in non-inflammatory neurological conditions, the molecular mechanisms involved are not fully determined. We previously showed that the acid-sensing ion channel 1 which, when activated under the acidotic tissue conditions found in inflammatory lesions opens to allow influx of sodium and calcium ions, contributes to axonal ...

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Publisher copy:
10.1093/brain/awq337

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Journal:
Brain More from this journal
Volume:
134
Issue:
2
Pages:
571-584
Publication date:
2011-02-01
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
Language:
English
Keywords:
Pubs id:
pubs:243864
UUID:
uuid:094456e6-5add-4c8e-8be8-b843f9a0484b
Local pid:
pubs:243864
Source identifiers:
243864
Deposit date:
2012-12-19

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