Journal article
The regulation of corticofugal fiber targeting by retinal inputs
- Abstract:
- Corticothalamic projection systems arise from 2 main cortical layers. Layer V neurons project exclusively to higher-order thalamic nuclei, while layer VIa fibers project to both first-order and higher-order thalamic nuclei. During early postnatal development, layer VIa and VIb fibers accumulate at the borders of the dorsal lateral geniculate nucleus (dLGN) before they innervate it. After neonatal monocular enucleation or silencing of the early retinal activity, there is premature entry of layer VIa and VIb fibers into the dLGN contralateral to the manipulation. Layer V fibers do not innervate the superficial gray layer of the superior colliculus during the first postnatal week, but also demonstrate premature entry to the contralateral superficial gray layer following neonatal enucleation. Normally, layer V driver projections to the thalamus only innervate higher-order nuclei. Our results demonstrate that removal of retinal input from the dLGN induces cortical layer V projections to aberrantly enter, arborize, and synapse within the first-order dLGN. These results suggest that there is cross-hierarchical corticothalamic plasticity after monocular enucleation. Cross-hierarchical rewiring has been previously demonstrated in the thalamocortical system (Pouchelon et al. 2014), and now we provide evidence for cross-hierarchical corticothalamic rewiring after loss of the peripheral sensory input.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.8MB, Terms of use)
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- Publisher copy:
- 10.1093/cercor/bhv315
Authors
- Publisher:
- Oxford University Press
- Journal:
- Cerebral Cortex More from this journal
- Volume:
- 26
- Issue:
- 3
- Pages:
- 1336-1348
- Place of publication:
- United States
- Publication date:
- 2016-01-06
- DOI:
- EISSN:
-
1460-2199
- ISSN:
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1047-3211
- Pmid:
-
26744542
- Language:
-
English
- Keywords:
- Pubs id:
-
588563
- Local pid:
-
pubs:588563
- Deposit date:
-
2020-04-02
Terms of use
- Copyright holder:
- Grant et al.
- Copyright date:
- 2016
- Rights statement:
- © The Author 2016. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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