HIV-1 attachment: another look.

Journal article

HIV-1 attachment to host cells is generally considered to take place via high-affinity binding between CD4 and gp120. However, the binding of virion-associated gp120 to cellular CD4 is often weak, and most cell types that are permissive for HIV-1 infection express little CD4. Thus, other interactions between the virion and the cell surface could dominate the attachment process.

Authors: Ugolini, S; Mondor, I; Sattentau, Q

• Publication status: Published
• Journal: Trends in microbiology
• Volume: 7
• Issue: 4
• Pages: 144-149
• Publication date: 1999-04-01
• DOI: 10.1016/s0966-842x(99)01474-2
• EISSN: 1878-4380
• ISSN: 0966-842X
• Language: English
• Keywords: Heparan Sulfate Proteoglycans; Antigens, CD4; HIV Envelope Protein gp120; Cell Adhesion Molecules; Receptors, Cell Surface; HIV Infections; HIV-1; Humans; Receptors, CXCR4; Receptors, CCR5