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Journal article

IGF signaling directs ventricular cardiomyocyte proliferation during embryonic heart development.

Abstract:

Secreted factors from the epicardium are believed to be important in directing heart ventricular cardiomyocyte proliferation and morphogenesis, although the specific factors involved have not been identified or characterized adequately. We found that IGF2 is the most prominent mitogen made by primary mouse embryonic epicardial cells and by a newly derived immortalized mouse embryonic epicardial cell line called MEC1. In vivo, Igf2 is expressed in the embryonic mouse epicardium during midgesta...

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Publication status:
Published

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Publisher copy:
10.1242/dev.054338

Authors


Journal:
Development (Cambridge, England) More from this journal
Volume:
138
Issue:
9
Pages:
1795-1805
Publication date:
2011-05-01
DOI:
EISSN:
1477-9129
ISSN:
0950-1991
Language:
English
Keywords:
Pubs id:
pubs:135126
UUID:
uuid:0937d966-2efc-48c1-a7e0-5ef0d7a920c7
Local pid:
pubs:135126
Source identifiers:
135126
Deposit date:
2012-12-19

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