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Maintenance of a normal thymic microenvironment and T-cell homeostasis require Smad4-mediated signaling in thymic epithelial cells.

Abstract:

Signals mediated by the transforming growth factor-beta superfamily of growth factors have been implicated in thymic epithelial cell (TEC) differentiation, homeostasis, and function, but a direct reliance on these signals has not been established. Here we demonstrate that a block in canonical transforming growth factor-beta signaling by the loss of Smad4 expression in TECs leads to qualitative changes in TEC function and a progressively disorganized thymic microenvironment. Moreover, the numb...

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Publication status:
Published

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Journal:
Blood More from this journal
Volume:
112
Issue:
9
Pages:
3688-3695
Publication date:
2008-11-01
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
Language:
English
Keywords:
Pubs id:
pubs:309036
UUID:
uuid:09369ded-aca9-4a42-9b0a-9acc170e308d
Local pid:
pubs:309036
Source identifiers:
309036
Deposit date:
2012-12-19

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