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Transcriptomic analysis of human primary breast cancer identifies fatty acid oxidation as a target for metformin

Abstract:

BACKGROUND:Epidemiological studies suggest that metformin may reduce the incidence of cancer in patients with diabetes and multiple late phase clinical trials assessing the potential of repurposing this drug are underway. Transcriptomic profiling of tumour samples is an excellent tool to understand drug bioactivity, identify candidate biomarkers and assess for mechanisms of resistance to therapy. METHODS:Thirty-six patients with untreated primary breast cancer were recruited to a window study...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41416-019-0665-5

Authors


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Institution:
University of Oxford
Department:
Oncology
Role:
Author
ORCID:
0000-0001-7946-5609
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Publisher:
Nature Research Publisher's website
Journal:
British Journal of Cancer Journal website
Volume:
122
Pages:
258–265
Publication date:
2019-12-10
Acceptance date:
2019-11-12
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
Pmid:
31819193
Source identifiers:
1077318
Language:
English
Keywords:
Pubs id:
pubs:1077318
UUID:
uuid:0935f6f7-5743-4532-8e19-117f61ca87d7
Local pid:
pubs:1077318
Deposit date:
2019-12-12

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