Journal article
FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations
- Abstract:
-
Accumulation of the DNA/RNA binding protein fused in sarcoma as cytoplasmic inclusions in neurons and glial cells is the pathological hallmark of all patients with amyotrophic lateral sclerosis with mutations in FUS as well as in several subtypes of frontotemporal lobar degeneration, which are not associated with FUS mutations. The mechanisms leading to inclusion formation and fused in sarcoma-associated neurodegeneration are only poorly understood. Because fused in sarcoma belongs to a famil...
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- Publisher copy:
- 10.1093/brain/awr201
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Authors
Bibliographic Details
- Journal:
- Brain
- Volume:
- 134
- Issue:
- 9
- Pages:
- 2595-2609
- Publication date:
- 2011-09-01
- DOI:
- EISSN:
-
1460-2156
- ISSN:
-
0006-8950
- Source identifiers:
-
244012
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:244012
- UUID:
-
uuid:09321ecf-6b78-42b9-ae8d-ea9fe4c14c58
- Local pid:
- pubs:244012
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2011
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