Journal article icon

Journal article

FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations

Abstract:

Accumulation of the DNA/RNA binding protein fused in sarcoma as cytoplasmic inclusions in neurons and glial cells is the pathological hallmark of all patients with amyotrophic lateral sclerosis with mutations in FUS as well as in several subtypes of frontotemporal lobar degeneration, which are not associated with FUS mutations. The mechanisms leading to inclusion formation and fused in sarcoma-associated neurodegeneration are only poorly understood. Because fused in sarcoma belongs to a famil...

Expand abstract

Actions


Access Document


Publisher copy:
10.1093/brain/awr201

Authors


Neumann, M More by this author
Bentmann, E More by this author
Dormann, D More by this author
Dejesus-Hernandez, M More by this author
Expand authors...
Journal:
Brain
Volume:
134
Issue:
9
Pages:
2595-2609
Publication date:
2011-09-05
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
URN:
uuid:09321ecf-6b78-42b9-ae8d-ea9fe4c14c58
Source identifiers:
244012
Local pid:
pubs:244012

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP