- Abstract:
-
Accumulation of the DNA/RNA binding protein fused in sarcoma as cytoplasmic inclusions in neurons and glial cells is the pathological hallmark of all patients with amyotrophic lateral sclerosis with mutations in FUS as well as in several subtypes of frontotemporal lobar degeneration, which are not associated with FUS mutations. The mechanisms leading to inclusion formation and fused in sarcoma-associated neurodegeneration are only poorly understood. Because fused in sarcoma belongs to a famil...
Expand abstract - Publisher copy:
- 10.1093/brain/awr201
-
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- Journal:
- Brain
- Volume:
- 134
- Issue:
- 9
- Pages:
- 2595-2609
- Publication date:
- 2011-09-05
- DOI:
- EISSN:
-
1460-2156
- ISSN:
-
0006-8950
- URN:
-
uuid:09321ecf-6b78-42b9-ae8d-ea9fe4c14c58
- Source identifiers:
-
244012
- Local pid:
- pubs:244012
- Language:
- English
- Keywords:
- Copyright date:
- 2011
Journal article
FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations
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