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Regulation of Foxp3+ inducible regulatory T cell stability by SOCS2.

Abstract:

Suppressor of cytokine signaling (SOCS) proteins are key regulators of CD4(+) T cell differentiation, and in particular, we have recently shown that SOCS2 inhibits the development of Th2 cells and allergic immune responses. Interestingly, transcriptome analyses have identified SOCS2 as being preferentially expressed in both natural regulatory T cells (Tregs) and inducible Tregs (iTregs); however, the role of SOCS2 in Foxp3(+) Treg function or development has not been fully elucidated. In this...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.1201396

Authors


Schiering, C More by this author
Carroll, HP More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
190
Issue:
7
Pages:
3235-3245
Publication date:
2013-04-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:0931bc25-af4c-4e7b-bf95-828f7d4b5c2b
Source identifiers:
387830
Local pid:
pubs:387830

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