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Nitric oxide modulates superoxide release and peroxynitrite formation in human blood vessels.

Abstract:

Nitric oxide and superoxide have important roles as vascular signaling molecules. Nitric oxide (NO) reacts rapidly with superoxide, producing peroxynitrite. The relative balance between these radicals has important implications for vascular pathophysiology in hypertension and other vascular disease states. However, the relationships between superoxide, NO, and peroxynitrite formation in human blood vessels remain unclear. Accordingly, we systematically measured NO, superoxide, and peroxynitri...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Role:
Author
Journal:
Hypertension
Volume:
39
Issue:
6
Pages:
1088-1094
Publication date:
2002-06-05
DOI:
EISSN:
1524-4563
ISSN:
0194-911X
URN:
uuid:091c4161-762d-495b-b495-6ccfa3dd7b8d
Source identifiers:
104953
Local pid:
pubs:104953

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