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Convergent total syntheses of (-)-rubriflordilactone B and (-)-pseudo-rubriflordilactone B

Abstract:

A highly convergent strategy for the synthesis of the natural product (-)-rubriflordilactone B, and the proposed structure of (-)-pseudo-rubriflordilactone B, is described. Late stage coupling of diynes containing the respective natural product FG rings with a common AB ring aldehyde precedes rhodium-catalyzed [2+2+2] alkyne cyclotrimerization to form the natural product skeleton, with the syntheses completed in just one further operation. This work resolves the uncertainty surrounding the id...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/anie.201908917

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Name:
Engineering and Physical Sciences Research Council
Grant:
EP/E055273/1
Publisher:
Wiley
Journal:
Angewandte Chemie International Edition More from this journal
Volume:
58
Issue:
50
Pages:
18177-18181
Publication date:
2019-10-08
Acceptance date:
2019-10-08
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
Pmid:
31595605
Language:
English
Keywords:
Pubs id:
pubs:1061695
UUID:
uuid:09170c4d-58e3-45d1-8276-b252ab84997c
Local pid:
pubs:1061695
Source identifiers:
1061695
Deposit date:
2019-10-31

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