Journal article
Convergent total syntheses of (-)-rubriflordilactone B and (-)-pseudo-rubriflordilactone B
- Abstract:
- A highly convergent strategy for the synthesis of the natural product (-)-rubriflordilactone B, and the proposed structure of (-)-pseudo-rubriflordilactone B, is described. Late stage coupling of diynes containing the respective natural product FG rings with a common AB ring aldehyde precedes rhodium-catalyzed [2+2+2] alkyne cyclotrimerization to form the natural product skeleton, with the syntheses completed in just one further operation. This work resolves the uncertainty surrounding the identity of pseudo-rubriflordilactone B, and provides a robust platform for further synthetic and biological investigations.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.8MB, Terms of use)
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- Publisher copy:
- 10.1002/anie.201908917
Authors
- Publisher:
- Wiley
- Journal:
- Angewandte Chemie International Edition More from this journal
- Volume:
- 58
- Issue:
- 50
- Pages:
- 18177-18181
- Publication date:
- 2019-10-08
- Acceptance date:
- 2019-10-08
- DOI:
- EISSN:
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1521-3773
- ISSN:
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1433-7851
- Pmid:
-
31595605
- Language:
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English
- Keywords:
- Pubs id:
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pubs:1061695
- UUID:
-
uuid:09170c4d-58e3-45d1-8276-b252ab84997c
- Local pid:
-
pubs:1061695
- Source identifiers:
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1061695
- Deposit date:
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2019-10-31
- ARK identifier:
Terms of use
- Copyright holder:
- Mohammad et al
- Copyright date:
- 2019
- Notes:
- ©2019 The Authors published by Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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