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Pharmacokinetics of oral and intravenous ofloxacin in children with multidrug-resistant typhoid fever.

Abstract:

The pharmacokinetics of oral and intravenous ofloxacin (7.5 mg.kg of body weight-1 given over 30 min) were studied in an open crossover study of 17 Vietnamese children, aged between 5 and 14 years, with acute uncomplicated typhoid fever. Following oral administration, the median (95% confidence interval [CI]) time to peak concentration of ofloxacin in serum (Cmax) was 1.7 h (1.4 to 1.9 h) and the mean (95% CI) Cmax was 5.5 mg.liter-1 (4.7 to 6.3 mg.liter-1) compared with a Cmax of 8.7 mg.lite...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
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Journal:
Antimicrobial agents and chemotherapy
Volume:
40
Issue:
9
Pages:
2167-2172
Publication date:
1996-09-01
EISSN:
1098-6596
ISSN:
0066-4804
Source identifiers:
45313

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