Substance-P antagonists: effect on spontaneous and drug-induced locomotor activity in the rat.

Journal article

The substance P (SP) antagonists (D-Pro4, D-Trp7,9, Leu11) SP(4-11), (D-Pro4, D-Trp7,9, Phe11)SP(4-11) and (D-Pro4, D-Trp7,9,10, Leu11) SP (4-11) were infused into the lateral ventricles (i.c.v.) and their effects on spontaneous and drug-induced locomotor activity were investigated. The drug DiMeC7, the stable substance P agonist, was used to stimulate locomotor activity because of its prolonged action. Only (D-Pro4, D-Trp7,9,10) SP (4-11) was found to attenuate the drug-induced increases in ...

Expand abstract

Authors: Elliott, P; Iversen, S

• Publication status: Published
• Journal: Neuropharmacology
• Volume: 26
• Issue: 5
• Pages: 419-422
• Publication date: 1987-05-01
• DOI: 10.1016/0028-3908(87)90021-9
• EISSN: 1873-7064
• ISSN: 0028-3908
• Language: English
• Keywords: Rats, Inbred Strains; Peptide Fragments; Male; Animals; Motor Activity; Pyrrolidonecarboxylic Acid; Brain; Substance P; Dopamine; Injections, Intraventricular; Rats