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Global contraction or local growth, bleb shape depends on more than just cell structure.

Abstract:

When the plasma membrane of a cell locally delaminates from its actin cortex the membrane is pushed outwards due to the cell׳s internal fluid pressure. The resulting spherical protrusion is known as a bleb. A cell׳s ability to function correctly is highly dependent on the production of such protrusions with the correct size and shape. Here, we investigate the nucleation of large blebs from small, local neck regions. A mathematical model of a cell׳s membrane, cortex and interconnecting adhesio...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jtbi.2015.04.023

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
More from this funder
Name:
European Commission
Funding agency for:
Goriely, A
More from this funder
Name:
St. John's College, Oxford
Funding agency for:
Woolley, T
Publisher:
Elsevier
Journal:
Journal of theoretical biology More from this journal
Volume:
380
Pages:
83-97
Publication date:
2015-09-01
DOI:
EISSN:
1095-8541
ISSN:
0022-5193
Language:
English
Keywords:
Pubs id:
pubs:521828
UUID:
uuid:09082130-4e96-4931-aabd-9256d9ced2da
Local pid:
pubs:521828
Source identifiers:
521828
Deposit date:
2015-07-21

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