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Differential corticospinal tract degeneration in homozygous 'D90A' SOD-1 ALS and sporadic ALS.

Abstract:

BACKGROUND: The homogeneous genotype and stereotyped phenotype of a unique familial form of amyotrophic lateral sclerosis (ALS) (patients homozygous for aspartate-to-alanine mutations in codon 90 (homD90A) superoxide dismutase 1) provides an ideal model for studying genotype/phenotype interactions and pathological features compared with heterogeneous apparently sporadic ALS. The authors aimed to use diffusion tensor tractography to quantify and compare changes in the intracerebral corticospin...

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Publication status:
Published

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Publisher copy:
10.1136/jnnp.2010.236018

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Journal:
Journal of neurology, neurosurgery, and psychiatry
Volume:
82
Issue:
8
Pages:
843-849
Publication date:
2011-08-05
DOI:
EISSN:
1468-330X
ISSN:
0022-3050
URN:
uuid:0905a761-b61a-4d30-9ee2-1cd9fada86d6
Source identifiers:
149729
Local pid:
pubs:149729

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