Journal article icon

Journal article

IRF5:RelA interaction targets inflammatory genes in macrophages.

Abstract:

Interferon Regulatory Factor 5 (IRF5) plays a major role in setting up an inflammatory macrophage phenotype, but the molecular basis of its transcriptional activity is not fully understood. In this study, we conduct a comprehensive genome-wide analysis of IRF5 recruitment in macrophages stimulated with bacterial lipopolysaccharide and discover that IRF5 binds to regulatory elements of highly transcribed genes. Analysis of protein:DNA microarrays demonstrates that IRF5 recognizes the canonical...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Journal:
Cell reports More from this journal
Volume:
8
Issue:
5
Pages:
1308-1317
Publication date:
2014-09-01
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
Language:
English
Pubs id:
pubs:483181
UUID:
uuid:090364ec-e993-4a83-b0a1-482aa66dd0f8
Local pid:
pubs:483181
Source identifiers:
483181
Deposit date:
2014-09-15

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP