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Age-associated losses of brain volume predict longitudinal cognitive declines over 8 to 20 years.

Abstract:

Absolute differences in global brain volume predict differences in cognitive ability among healthy older adults. However, absolute differences confound lifelong differences in brain size with amounts of age-related shrinkage. Measurements of cerebrospinal fluid (CSF) volume were made to estimate age-related shrinkage in 93 healthy volunteers aged 63 to 86 years. Their current levels of brain shrinkage predicted their amounts of decline over the previous 8 to 20 years on repeated assessments d...

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Publication status:
Published

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Publisher copy:
10.1037/0894-4105.22.1.3

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Ibrahim, S More by this author
Thacker, N More by this author
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Journal:
Neuropsychology
Volume:
22
Issue:
1
Pages:
3-9
Publication date:
2008-01-05
DOI:
EISSN:
1931-1559
ISSN:
0894-4105
URN:
uuid:09001fc1-43dc-4041-a33f-0405cf9249df
Source identifiers:
17587
Local pid:
pubs:17587

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