Apparent Mendelian inheritance of breast and colorectal cancer: chance, genetic heterogeneity or a new gene?

Journal article

It is not uncommon for cancer geneticists to be referred families with apparently Mendelian co-inheritance of breast and bowel cancer. Such families present a particular problem as regards the intensity of their screening for these diseases and the utility of genetic testing. Many 'breast-colon' cancer families probably result from chance clustering of two common cancers. Other 'breast-colon' cancer families may result from known cancer syndromes, such as hereditary breast-ovarian cancer or h...

Expand abstract

Authors: Lipton, L; Thomas, H; Eeles, R; Houlston, R; Longmuir, M

• Journal: Familial cancer
• Volume: 1
• Issue: 3-4
• Pages: 189-195
• Publication date: 2001-01-01
• DOI: 10.1023/a:1021101014264
• EISSN: 1573-7292
• ISSN: 1389-9600
• Language: English
• Keywords: Gene Frequency; Humans; Phenotype; Genes, APC; Colorectal Neoplasms; Female; Breast Neoplasms; Male; Protein-Serine-Threonine Kinases; Genetic Heterogeneity; Mutation; Pedigree; Genetic Predisposition to Disease; Adult