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Journal article

c-Myb and GATA-1 alternate dominant roles during megakaryocyte differentiation.

Abstract:

BACKGROUND: Transcription factors are essential for blood cell formation. Mice expressing low levels of c-Myb (c-Myb(low)) have an increased number of bone marrow megakaryocytes (MKs) and corresponding thrombocytosis. In contrast, mice engineered to express low levels of GATA-1 (GATA-1(low)) in the megakaryocytic lineage exhibit aberrant megakaryocytopoiesis with hyperproliferation of progenitors and defective terminal differentiation leading to thrombocytopenia. These seemingly opposite role...

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Publication status:
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Authors


García, P More by this author
Berlanga, O More by this author
Vegiopoulos, A More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, Biomedical Research
Frampton, J More by this author
Journal:
Journal of thrombosis and haemostasis : JTH
Volume:
9
Issue:
8
Pages:
1572-1581
Publication date:
2011-08-05
DOI:
EISSN:
1538-7836
ISSN:
1538-7933
URN:
uuid:08ee45ca-3a5f-4e5c-bcf0-a1b9b08cd0de
Source identifiers:
154917
Local pid:
pubs:154917

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