- Abstract:
-
BACKGROUND: Transcription factors are essential for blood cell formation. Mice expressing low levels of c-Myb (c-Myb(low)) have an increased number of bone marrow megakaryocytes (MKs) and corresponding thrombocytosis. In contrast, mice engineered to express low levels of GATA-1 (GATA-1(low)) in the megakaryocytic lineage exhibit aberrant megakaryocytopoiesis with hyperproliferation of progenitors and defective terminal differentiation leading to thrombocytopenia. These seemingly opposite role...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1111/j.1538-7836.2011.04396.x
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- Journal:
- Journal of thrombosis and haemostasis : JTH
- Volume:
- 9
- Issue:
- 8
- Pages:
- 1572-1581
- Publication date:
- 2011-08-05
- DOI:
- EISSN:
-
1538-7836
- ISSN:
-
1538-7933
- URN:
-
uuid:08ee45ca-3a5f-4e5c-bcf0-a1b9b08cd0de
- Source identifiers:
-
154917
- Local pid:
- pubs:154917
- Language:
- English
- Keywords:
- Copyright date:
- 2011
Journal article
c-Myb and GATA-1 alternate dominant roles during megakaryocyte differentiation.
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