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Regulatory T cells as modulators of chronic allograft dysfunction.

Abstract:

Chronic allograft dysfunction (CAD) in solid organ transplantation is a principal cause of patient morbidity and late allograft loss. The pathogenesis of CAD is largely secondary to chronic damage by the adaptive immune system and long-term immunosuppression. Manipulating these factors may be possible with the use of regulatory T cells (Treg), which have the ability to suppress specific immune responses and therefore potentially remove the need for immunosuppressive drugs. Studies of CAD in e...

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Publication status:
Published

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Publisher copy:
10.1016/j.coi.2011.06.005

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
Journal:
Current opinion in immunology
Volume:
23
Issue:
5
Pages:
648-654
Publication date:
2011-10-01
DOI:
EISSN:
1879-0372
ISSN:
0952-7915
Source identifiers:
166469

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