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PPARdelta in humans: genetic and pharmacological evidence for a significant metabolic function.

Abstract:

PURPOSE OF REVIEW: Abundant data in rodents suggest an important role for peroxisomal proliferators-activated receptor-delta (PPARdelta) in regulating skeletal muscle fatty acid oxidation and this has consequences for lipid and lipoprotein metabolism. Considerably less is known in humans and this review will focus on evidence derived from studies of the PPARD gene and pharmacological use of specific PPARdelta agonists. RECENT FINDINGS: Genetic association studies of single-nucleotide polymor...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM, Biomedical Research Centre
Ehrenborg, EE More by this author
Journal:
Current opinion in lipidology
Volume:
20
Issue:
4
Pages:
333-336
Publication date:
2009-08-05
DOI:
EISSN:
1473-6535
ISSN:
0957-9672
URN:
uuid:08e8e501-acb0-4b24-97f3-d589ccc49119
Source identifiers:
19117
Local pid:
pubs:19117

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