Journal article
A common polymorphism in the retinoic acid pathway modifies adrenocortical carcinoma age-dependent incidence
- Abstract:
-
Background: Genome-wide association studies (GWASs) have enriched the fields of genomics and drug development. Adrenocortical carcinoma (ACC) is a rare cancer with a bimodal age distribution and inadequate treatment options. Paediatric ACC is frequently associated with TP53 mutations, with particularly high incidence in Southern Brazil due to the TP53 p.R337H (R337H) germline mutation. The heterogeneous risk among carriers suggest...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- British Journal of Cancer Journal website
- Volume:
- 122
- Pages:
- 1231–1241
- Publication date:
- 2020-03-09
- Acceptance date:
- 2019-12-20
- DOI:
- EISSN:
-
1532-1827
- ISSN:
-
0007-0920
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:1081432
- UUID:
-
uuid:08e5c4c8-8fa1-436d-b15d-e07a861bc638
- Local pid:
- pubs:1081432
- Source identifiers:
-
1081432
- Deposit date:
- 2020-01-09
Terms of use
- Copyright holder:
- Surakhy et al.
- Copyright date:
- 2020
- Rights statement:
- Copyright © 2020 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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