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Molecular determinants of origin discrimination by Orc1 initiators in archaea.

Abstract:

Unlike bacteria, many eukaryotes initiate DNA replication from genomic sites that lack apparent sequence conservation. These loci are identified and bound by the origin recognition complex (ORC), and subsequently activated by a cascade of events that includes recruitment of an additional factor, Cdc6. Archaeal organisms generally possess one or more Orc1/Cdc6 homologs, belonging to the Initiator clade of ATPases associated with various cellular activities (AAA(+)) superfamily; however, these ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/nar/gkq1308

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Funding agency for:
Bell, SD
Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic acids research Journal website
Volume:
39
Issue:
9
Pages:
3621-3631
Publication date:
2011-05-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:08e520d6-5aa7-4335-ac5d-7d36c9f2f97a
Source identifiers:
112515
Local pid:
pubs:112515

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