Journal article icon

Journal article

Selective targeting of death receptor 5 circumvents resistance of MG-63 osteosarcoma cells to TRAIL-induced apoptosis.

Abstract:

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a tumor necrosis factor superfamily member, targets death receptors and selectively kills malignant cells while leaving normal cells unaffected. However, unlike most cancers, many osteosarcomas are resistant to TRAIL. To investigate this resistance, we characterized the response of MG-63 osteosarcoma cells and hPOB-tert osteoblast-like cells to TRAIL and agonist antibodies to death receptor 4 (DR4) and death receptor 5 (DR5). We...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Expand authors...
Journal:
Molecular cancer therapeutics
Volume:
6
Issue:
12 Pt 1
Pages:
3219-3228
Publication date:
2007-12-01
DOI:
EISSN:
1538-8514
ISSN:
1535-7163
Source identifiers:
8992
Language:
English
Keywords:
Pubs id:
pubs:8992
UUID:
uuid:08df89fc-9c9b-4e4b-b375-b55d6b0ea5ba
Local pid:
pubs:8992
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP