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Activation of the innate immune response by endogenous retroviruses.

Abstract:

The human genome comprises 8 % endogenous retroviruses (ERVs), the majority of which are defective due to deleterious mutations. Nonetheless, transcripts of ERVs are found in most tissues, and these transcripts could either be reverse transcribed to generate ssDNA or expressed to generate proteins. Thus, the expression of ERVs could produce nucleic acids or proteins with viral signatures, much like the pathogen-associated molecular patterns of exogenous viruses, which would enable them to be ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1099/jgv.0.000017

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
More from this funder
Name:
Medical Research Council
Funding agency for:
Hurst, T
Magiorkinis, G
Grant:
Clinician Scientist Fellowship
Publisher:
Microbiology Society
Journal:
Journal of General Virology More from this journal
Volume:
96
Issue:
6
Pages:
1207-1218
Publication date:
2015-06-01
DOI:
EISSN:
1465-2099
ISSN:
0022-1317
Language:
English
Pubs id:
pubs:501541
UUID:
uuid:08dd3301-5bdd-4b5b-8cf2-a6ce10489c72
Local pid:
pubs:501541
Source identifiers:
501541
Deposit date:
2016-02-08

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