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Journal article

Virological footprint of CD4+ T-cell responses during chronic hepatitis C virus infection

Abstract:

Human and animal model evidence suggests that CD4⁺ T cells play a critical role in the control of chronic hepatitis C virus (HCV) infection. However, despite their importance, the mechanism behind the failure of such populations in chronic disease is not understood and the contribution of viral mutation is not known. To address this, this study defined the specificity and virological footprint of CD4⁺ T cells in chronic infection. CD8⁺ T-cell-depleted peripheral blood mononuclear cells from 6...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1099/vir.0.017699-0

Authors


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Institution:
University of Oxford
Division:
MSD
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Role:
Author
Publisher:
Society for General Microbiology
Journal:
Journal of General Virology More from this journal
Volume:
91
Issue:
6
Pages:
1396-1406
Publication date:
2010-06-01
DOI:
EISSN:
1465-2099
ISSN:
0022-1317
Language:
English
Keywords:
Subjects:
UUID:
uuid:08d99aee-3445-414f-adc1-94cc1f322778
Local pid:
ora:6035
Deposit date:
2012-01-25

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