A polymorphism in human CD1A is associated with susceptibility to tuberculosis

Journal article

CD1 proteins are antigen-presenting molecules that evolved to present lipids rather than peptides to T cells. However, unlike major histocompatibility complex genes, CD1 genes show low rates of polymorphism and have not been clearly associated with human disease. We report that an intronic polymorphism in CD1A (rs411089) is associated with susceptibility to tuberculosis in two cohorts of Vietnamese adults (combined cohort odds ratio 1.78; 95% confidence interval: 1.24-2.57; P=0.001). These da...

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Authors: Seshadri, C; Thuong, N; Yen, N; Bang, N; Chau, T

• Publisher: Nature Publishing Group
• Journal: Genes and Immunity
• Volume: 15
• Issue: 3
• Pages: 195-198
• Publication date: 2014-01-01
• DOI: 10.1038/gene.2014.5
• EISSN: 1476-5470
• ISSN: 1466-4879
• Language: English
• Keywords: host response; human; tuberculosis; CD1A; single-nucleotide polymorphism; genetic association