Efficacy markers in depression.

Journal article

Current antidepressant agents are similar in efficacy to the original drugs discovered in the 1950s. The development of new treatments for depression is, however, limited by the absence of validated human biomarker models to predict efficacy, clinical profile and dosing. Such models need to meet key criteria for biomarkers including sensitivity, specificity and relevance to depression. Here we review studies exploring whether early changes in emotional processing with antidepressant drug admi...

Expand abstract

Authors: Harmer, C; Cowen, P; Goodwin, G

• Publication status: Published
• Journal: Journal of psychopharmacology (Oxford, England)
• Volume: 25
• Issue: 9
• Pages: 1148-1158
• Publication date: 2011-09-01
• DOI: 10.1177/0269881110367722
• EISSN: 1461-7285
• ISSN: 0269-8811
• Language: English
• Keywords: Clinical Trials as Topic; Drug Design; Depressive Disorder, Major; Humans; Emotions; Validation Studies as Topic; Biomarkers, Pharmacological; Decision Making; Sensitivity and Specificity; Animals; Antidepressive Agents