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Inhibition of centrosome separation after DNA damage: a role for Nek2.

Abstract:

DNA damage results in cell cycle arrest in G2. Centrosomes also separate in G2, raising the question of whether separation occurs during the DNA damage-induced G2 arrest. Nek2, the mammalian homologue of NIMA, is a cell cycle-regulated serine/threonine protein kinase that regulates centrosome separation during G2. Here we show that damaged cells fail to activate Nek2. Both Nek2 levels and activity are reduced after DNA damage. Radiation inhibits the premature centrosome splitting induced by o...

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Publication status:
Published

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Publisher copy:
10.1667/rr3211

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
Radiation research More from this journal
Volume:
162
Issue:
2
Pages:
128-135
Publication date:
2004-08-01
DOI:
EISSN:
1938-5404
ISSN:
0033-7587
Language:
English
Keywords:
Pubs id:
pubs:131273
UUID:
uuid:08c7b319-9025-4ab3-95a4-2f27658a2f34
Local pid:
pubs:131273
Source identifiers:
131273
Deposit date:
2012-12-19

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