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Comparison of conventional bacteriology with nucleic acid amplification (amplified mycobacterium direct test) for diagnosis of tuberculous meningitis before and after inception of antituberculosis chemotherapy.

Abstract:

The role of nucleic acid amplification techniques in the rapid diagnosis of tuberculous meningitis remains uncertain. We compared the performance of Ziehl-Neelsen (ZN) staining, the Gen-Probe amplified Mycobacterium tuberculosis direct test (MTD), and culture with 341 cerebrospinal fluid specimens from 152 adults (73 with and 79 without tuberculous meningitis) before and after inception of antituberculosis chemotherapy. The sensitivity, specificity, and positive and negative predictive values...

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Publication status:
Published

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Authors


Thwaites, GE More by this author
Campbell, JI More by this author
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Journal:
Journal of clinical microbiology
Volume:
42
Issue:
3
Pages:
996-1002
Publication date:
2004-03-05
DOI:
EISSN:
1098-660X
ISSN:
0095-1137
URN:
uuid:08c33fd6-517b-4a5c-94ce-9bcb7267c1b2
Source identifiers:
32649
Local pid:
pubs:32649

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