Longitudinal analysis of CD8 T-cell responses to HIV and hepatitis C virus in a cohort of co-infected haemophiliacs.

Journal article

OBJECTIVE: To investigate CD8 T-cell responses to HIV and hepatitis C virus (HCV) over time in a group of co-infected children with haemophilia to assess the influence of the virus infections on each other and on clinical outcome. DESIGN: The HIV and HCV CD8 T-cell response of HLA-A2 co-infected individuals in the cohort were analysed at two time points, looking at the frequency and phenotype of HIV-specific T cells and assessing overall responses to the two viruses. METHODS: Peripheral bloo...

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Authors: Harcourt, G; Donfield, S; Gomperts, E; Daar, E; Goulder, P

• Publication status: Published
• Journal: AIDS (London, England)
• Volume: 19
• Issue: 11
• Pages: 1135-1143
• Publication date: 2005-07-01
• DOI: 10.1097/01.aids.0000176213.10367.05
• EISSN: 1473-5571
• ISSN: 0269-9370
• Language: English
• Keywords: Longitudinal Studies; Adult; Hemophilia A; Immunity, Cellular; CD8-Positive T-Lymphocytes; Hemophilia Growth and Development Study (HGDS); Phenotype; Child; Cohort Studies; Adolescent; Enzyme-Linked Immunosorbent Assay; Hepatitis C; Humans; HIV Infections